Hematopoietic stem cell: self-renewal versus differentiation

Deterministic regulation of hematopoietic stem cell self-renewal and differentiation.

Most current theories assume that self-renewal and differentiation of hematolymphoid stem cells (HSCs) is randomly regulated by intrinsic and environmental influences. A direct corollary of these tenets is that self-renewal will continuously generate functionally heterogeneous daughter HSCs. Decisions about self-renewal versus commitment are made by individual, single HSCs and, thus, require ex...

Regulation of hematopoietic stem cell self-renewal.

Every day, billions of new blood cells are produced in the body, each one derived from a hematopoietic stem cell (HSC). Because most mature blood stem cells have a limited life span, the ability of HSCs to perpetuate themselves through self-renewal and generate new blood cells for the lifetime of an organism is critical to sustaining life. A key problem in hematopoietic stem cell biology is how...

Heterogeneity, Self-Renewal, and Differentiation of Hematopoietic Stem Cells

1Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA 2Department of Pathology and Laboratory Medicine, Stowers Institute for Medical Research, University of Kansas School of Medicine, Kansas City, MO 64110, USA 3Terry Fox Laboratory, British Columbia Cancer Agency and Department of Medicine, Unive...

Self-renewal and differentiation of hematopoietic stem cells.

Hematopoietic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into all blood lineage cells. The fate decisions of HSCs (self-renewal versus differentiation) are made through the process of cell division and are often compared to "birth" and "death". Stem cells give rise to undifferentiated stem cells (birth) or differentiate into progenitor cells (death). Th...

Networks Establishing Hematopoietic Stem Cell Multipotency and Self-Renewal